Lymedisease is a tick-borne illness caused by the spirochete B burgdorferi. Lymedisease can be divided into early disease (stage 1, EM), disseminated infection (stage 2), and late disease (stage 3, persistent infection). The first stage involves the skin, followed by stages 2 and 3, which often affect the skin, joints, CNS, and heart. However, any of the stages may fail to appear or may overlap with one another
| Stage | Timing |
|---|---|
| Localized erythema chronicum migrans | Early infection |
| Disseminated infection | Within days or years |
| Persistent infection | Months to years |