Lyme Disease Update Review
Information on lyme disease symptoms,sign,diagnosis,treatment and complication.This is an infectious disease caused by ticks infected with Borrelia burgdorferi.
Pathogenesis of Lyme Disease
Pathogenesis of lyme disease. After inoculation in the skin, B burgdorferi replicates within the dermis producing EM and spreads hematogenously to other organs. The organism has tropism for the skin, joints, heart and CNS. A rise in immunoglobulin M (IgM) is detected within 2-3 weeks after the onset of infection; an increase in IgG and IgA is established after 2-3 months of infection. Host genetic factors may determine the likelihood of tissue damage; for example, patients with human leukocyte antigens DR4 and DR2 may be more susceptible to chronic arthritis.
